Revolutionary Process

How LightPico Works

Discover the breakthrough science behind our AI-driven optical microscopy that achieves electron microscopy resolution through innovative picophotonics technology.

Optical microscopy with Electron microscopy resolution?

Microscopy Comparison - Optical vs Electron Microscopes

Our solution:

"label-free, non-invasive, concise setup and easy to operate"

Engineer:

Nano-machines / Semiconductor Fab / Biomedical…

Science:

Brownian motion / Viruses research …

Applications:

Semiconductor, Biomedicine, Material

Technical Innovation

AI-driven optical technique achieving electron microscopy resolution

1
Optical scheme
Camera
Imaging System
Sample
Coherent illumination
2
Training of neural network
Sample 1, 2, n
Scattering Pattern 1, 2, n
Artificial Intelligence
3
Metrology and imaging of nano object
Unseen scattering pattern
Number, positions, sizes
image-reconstruction of nano objects

5% of electron microscope costs, Simple sample preparation, low power, no toxic dyes, Long time service

AI-enabled super-resolution close to electron microscopy level

Pico-level optical metrology without fluorescent labeling

Achievements (CRP Projects)

1D static metrology
Diffraction pattern
width and position
Resolution ~ λ/800

C. Rendon-Barraza et.al., APL Photonics 6, 066107 (2021)

2D static metrology
Long axis Short axis
long-axis retrieval: λ/28
short-axis retrieval: λ/94

Wang et.al., Conference on Lasers and Electro-Optics Europe (CLEO-Europe (2023)

1D dynamic metrology
Nanowire setup
Displacement of nanowire 0V 2V
Resolution ~ λ/10000

Liu, Tongjun, et al. Nature Materials 22.7 (2023): 844-847.

2D multiple-objects metrology
Diffraction pattern
Prediction
SEM
Multiple subwavelength nanoparticle (λ/3.2)

Chan et.al, Nanophotonics 12.14 (2023): 2807-2812.

Label-free far-field optical imaging with deeply subwavelength resolution

Achievements (CRP Projects)

2D nanoparticle imaging
Super-resolution artificial neural network
λ/6 nanoparticles closely packed

Wang et.al., Appl. Phys. Lett. 124 151105 (2024)

Arbitrary shape pixelate imaging
Image by image reconstruction process
Patent pending (2024)

Training: Corresponding diffraction patterns → Optical LEGO

Arbitrary shape continuous imaging

AI-Imaging Reconstruction

AI Imaging Reconstruction
Resolution = λ/10.8

Confocal Imaging

Confocal Imaging
Resolution = λ/3.9
Patent pending(2024)

Microscopy set-up

Imaging set-up in acoustic chamber

Imaging set-up in acoustic chamber

acoustic enclosure • sample stage • objective/SOL lens • 633nm laser • sample • QWP • linear polarizer • camera

Optical path diagram
laser → collimator → polarizer → QWP
objective (100x, 0.9NA) → sample → objective (100x, 0.9NA)
QWP → polarizer → CCD → Neural Network

Experience the Technology

Ready to see LightPico's revolutionary microscopy in action? Schedule a demonstration or explore our detailed technical specifications.